Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4780034..4780636 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW58_RS23175 Protein ID WP_000897305.1
Coordinates 4780325..4780636 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW58_RS23170 Protein ID WP_000356397.1
Coordinates 4780034..4780324 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS23145 (4775979) 4775979..4776881 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW58_RS23150 (4776878) 4776878..4777513 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW58_RS23155 (4777510) 4777510..4778439 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW58_RS23160 (4778769) 4778769..4779011 - 243 WP_001087409.1 protein YiiF -
QDW58_RS23165 (4779230) 4779230..4779448 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW58_RS23170 (4780034) 4780034..4780324 - 291 WP_000356397.1 NadS family protein Antitoxin
QDW58_RS23175 (4780325) 4780325..4780636 - 312 WP_000897305.1 hypothetical protein Toxin
QDW58_RS23180 (4780865) 4780865..4781773 + 909 WP_001162704.1 alpha/beta hydrolase -
QDW58_RS23185 (4781837) 4781837..4782778 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW58_RS23190 (4782823) 4782823..4783260 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QDW58_RS23195 (4783257) 4783257..4784129 - 873 WP_000920762.1 virulence factor BrkB family protein -
QDW58_RS23200 (4784123) 4784123..4784722 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277425 WP_000897305.1 NZ_CP122629:c4780636-4780325 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT277425 WP_000356397.1 NZ_CP122629:c4780324-4780034 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References