277400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3713503..3714044 Replicon chromosome
Accession NZ_CP122625
Organism Escherichia coli strain ETEC4089

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QDW64_RS18430 Protein ID WP_000615983.1
Coordinates 3713766..3714044 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QDW64_RS18425 Protein ID WP_000729703.1
Coordinates 3713503..3713763 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW64_RS18405 (3709178) 3709178..3709963 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QDW64_RS18410 (3709935) 3709935..3711647 + 1713 Protein_3602 flagellar biosynthesis protein FlhA -
QDW64_RS18415 (3711871) 3711871..3712368 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QDW64_RS18420 (3712544) 3712544..3713293 - 750 WP_000056849.1 C40 family peptidase -
QDW64_RS18425 (3713503) 3713503..3713763 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDW64_RS18430 (3713766) 3713766..3714044 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDW64_RS18435 (3714200) 3714200..3714940 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDW64_RS18440 (3714911) 3714911..3715678 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDW64_RS18445 (3715884) 3715884..3716462 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T277400 WP_000615983.1 NZ_CP122625:3713766-3714044 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT277400 WP_000729703.1 NZ_CP122625:3713503-3713763 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References