277390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1828704..1829206 Replicon chromosome
Accession NZ_CP122625
Organism Escherichia coli strain ETEC4089

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8E0FJZ4
Locus tag QDW64_RS08905 Protein ID WP_000767833.1
Coordinates 1828952..1829206 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDW64_RS08900 Protein ID WP_001259255.1
Coordinates 1828704..1828955 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW64_RS08875 (1823882) 1823882..1824949 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDW64_RS08880 (1824949) 1824949..1826019 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
QDW64_RS08885 (1826022) 1826022..1827320 - 1299 WP_049290931.1 histidinol dehydrogenase -
QDW64_RS08890 (1827326) 1827326..1828225 - 900 WP_000131756.1 ATP phosphoribosyltransferase -
QDW64_RS08895 (1828371) 1828371..1828421 - 51 WP_001364200.1 his operon leader peptide -
QDW64_RS08900 (1828704) 1828704..1828955 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDW64_RS08905 (1828952) 1828952..1829206 + 255 WP_000767833.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDW64_RS08910 (1829289) 1829289..1830113 + 825 WP_000754758.1 SDR family oxidoreductase -
QDW64_RS08915 (1830159) 1830159..1831088 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDW64_RS08920 (1831302) 1831302..1831364 + 63 WP_010723108.1 membrane protein YoeI -
QDW64_RS08925 (1831354) 1831354..1832712 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDW64_RS08930 (1832891) 1832891..1833949 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
QDW64_RS08935 (1833963) 1833963..1834190 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10173.54 Da        Isoelectric Point: 8.0353

>T277390 WP_000767833.1 NZ_CP122625:1828952-1829206 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT277390 WP_001259255.1 NZ_CP122625:1828704-1828955 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References