Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4226134..4226675 Replicon chromosome
Accession NZ_CP122620
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QDW69_RS21535 Protein ID WP_000615983.1
Coordinates 4226397..4226675 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QDW69_RS21530 Protein ID WP_000729703.1
Coordinates 4226134..4226394 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS21510 (4221809) 4221809..4222594 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QDW69_RS21515 (4222566) 4222566..4224278 + 1713 Protein_4212 flagellar biosynthesis protein FlhA -
QDW69_RS21520 (4224502) 4224502..4224999 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QDW69_RS21525 (4225175) 4225175..4225924 - 750 WP_000056849.1 C40 family peptidase -
QDW69_RS21530 (4226134) 4226134..4226394 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDW69_RS21535 (4226397) 4226397..4226675 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDW69_RS21540 (4226831) 4226831..4227571 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDW69_RS21545 (4227542) 4227542..4228309 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDW69_RS21550 (4228515) 4228515..4229093 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T277369 WP_000615983.1 NZ_CP122620:4226397-4226675 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT277369 WP_000729703.1 NZ_CP122620:4226134-4226394 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References