Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1961828..1962330 Replicon chromosome
Accession NZ_CP122620
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QDW69_RS09595 Protein ID WP_000767829.1
Coordinates 1962076..1962330 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S1Y4D6
Locus tag QDW69_RS09590 Protein ID WP_001259254.1
Coordinates 1961828..1962079 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS09565 (1957006) 1957006..1958073 - 1068 WP_016232166.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDW69_RS09570 (1958073) 1958073..1959143 - 1071 WP_000108986.1 histidinol-phosphate transaminase -
QDW69_RS09575 (1959140) 1959140..1960444 - 1305 WP_046788605.1 histidinol dehydrogenase -
QDW69_RS09580 (1960450) 1960450..1961349 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QDW69_RS09585 (1961495) 1961495..1961545 - 51 WP_001364200.1 his operon leader peptide -
QDW69_RS09590 (1961828) 1961828..1962079 + 252 WP_001259254.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDW69_RS09595 (1962076) 1962076..1962330 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDW69_RS09600 (1962413) 1962413..1963237 + 825 WP_000754737.1 SDR family oxidoreductase -
QDW69_RS09605 (1963283) 1963283..1964212 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDW69_RS09610 (1964427) 1964427..1964489 + 63 WP_010723108.1 membrane protein YoeI -
QDW69_RS09615 (1964479) 1964479..1965837 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDW69_RS09620 (1966015) 1966015..1967073 + 1059 WP_000492313.1 thiosulfate utilization transporter TsuA/YeeE -
QDW69_RS09625 (1967087) 1967087..1967314 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T277352 WP_000767829.1 NZ_CP122620:1962076-1962330 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9292.57 Da        Isoelectric Point: 4.5822

>AT277352 WP_001259254.1 NZ_CP122620:1961828-1962079 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGIGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A2S1Y4D6

References