Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 612133..612932 Replicon chromosome
Accession NZ_CP122620
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDW69_RS03005 Protein ID WP_000347273.1
Coordinates 612133..612597 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW69_RS03010 Protein ID WP_001307405.1
Coordinates 612597..612932 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS02975 (607134) 607134..607568 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW69_RS02980 (607586) 607586..608464 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW69_RS02985 (608454) 608454..609233 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW69_RS02990 (609244) 609244..609717 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW69_RS02995 (609740) 609740..611020 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW69_RS03000 (611269) 611269..612078 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDW69_RS03005 (612133) 612133..612597 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW69_RS03010 (612597) 612597..612932 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW69_RS03015 (613081) 613081..614652 - 1572 WP_001273753.1 galactarate dehydratase -
QDW69_RS03020 (615027) 615027..616361 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDW69_RS03025 (616377) 616377..617147 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277346 WP_000347273.1 NZ_CP122620:c612597-612133 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277346 WP_001307405.1 NZ_CP122620:c612932-612597 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References