277343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4662890..4663492 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW52_RS22570 Protein ID WP_000897305.1
Coordinates 4663181..4663492 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW52_RS22565 Protein ID WP_000356397.1
Coordinates 4662890..4663180 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS22540 (4658815) 4658815..4659717 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW52_RS22545 (4659714) 4659714..4660349 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW52_RS22550 (4660346) 4660346..4661275 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW52_RS22555 (4661605) 4661605..4661847 - 243 WP_001087409.1 protein YiiF -
QDW52_RS22560 (4662067) 4662067..4662285 - 219 WP_001315930.1 CopG family transcriptional regulator -
QDW52_RS22565 (4662890) 4662890..4663180 - 291 WP_000356397.1 NadS family protein Antitoxin
QDW52_RS22570 (4663181) 4663181..4663492 - 312 WP_000897305.1 hypothetical protein Toxin
QDW52_RS22575 (4663721) 4663721..4664629 + 909 WP_001162704.1 alpha/beta hydrolase -
QDW52_RS22580 (4664693) 4664693..4665634 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW52_RS22585 (4665679) 4665679..4666116 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QDW52_RS22590 (4666113) 4666113..4666985 - 873 WP_000920762.1 virulence factor BrkB family protein -
QDW52_RS22595 (4666979) 4666979..4667578 - 600 WP_001295269.1 glucose-1-phosphatase -
QDW52_RS22600 (4667677) 4667677..4668462 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277343 WP_000897305.1 NZ_CP122617:c4663492-4663181 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT277343 WP_000356397.1 NZ_CP122617:c4663180-4662890 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References