Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3751491..3752032 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QDW52_RS18345 Protein ID WP_000615976.1
Coordinates 3751754..3752032 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QDW52_RS18340 Protein ID WP_000729704.1
Coordinates 3751491..3751751 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS18315 (3747274) 3747274..3748059 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
QDW52_RS18320 (3748031) 3748031..3749743 + 1713 Protein_3585 flagellar biosynthesis protein FlhA -
QDW52_RS18325 (3749848) 3749848..3750126 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QDW52_RS18330 (3750119) 3750119..3750475 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QDW52_RS18335 (3750532) 3750532..3751305 - 774 WP_000543895.1 C40 family peptidase -
QDW52_RS18340 (3751491) 3751491..3751751 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDW52_RS18345 (3751754) 3751754..3752032 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDW52_RS18350 (3752188) 3752188..3752928 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDW52_RS18355 (3752899) 3752899..3753666 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDW52_RS18360 (3753872) 3753872..3754450 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 3750119..3768017 17898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T277339 WP_000615976.1 NZ_CP122617:3751754-3752032 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT277339 WP_000729704.1 NZ_CP122617:3751491-3751751 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References