277328

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1806457..1806959 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QDW52_RS08685 Protein ID WP_000767829.1
Coordinates 1806705..1806959 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDW52_RS08680 Protein ID WP_001259255.1
Coordinates 1806457..1806708 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS08655 (1801634) 1801634..1802701 - 1068 WP_000080090.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDW52_RS08660 (1802701) 1802701..1803771 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
QDW52_RS08665 (1803768) 1803768..1805072 - 1305 WP_001446927.1 histidinol dehydrogenase -
QDW52_RS08670 (1805078) 1805078..1805977 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QDW52_RS08675 (1806123) 1806123..1806173 - 51 WP_001364200.1 his operon leader peptide -
QDW52_RS08680 (1806457) 1806457..1806708 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDW52_RS08685 (1806705) 1806705..1806959 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDW52_RS08690 (1807042) 1807042..1807866 + 825 WP_000754737.1 SDR family oxidoreductase -
QDW52_RS08695 (1807912) 1807912..1808841 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDW52_RS08700 (1809056) 1809056..1809118 + 63 WP_010723108.1 membrane protein YoeI -
QDW52_RS08705 (1809108) 1809108..1810466 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDW52_RS08710 (1810645) 1810645..1811703 + 1059 WP_000492330.1 thiosulfate utilization transporter TsuA/YeeE -
QDW52_RS08715 (1811717) 1811717..1811944 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T277328 WP_000767829.1 NZ_CP122617:1806705-1806959 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT277328 WP_001259255.1 NZ_CP122617:1806457-1806708 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References