Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 592683..593482 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag QDW52_RS02890 Protein ID WP_000347266.1
Coordinates 592683..593147 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW52_RS02895 Protein ID WP_001307405.1
Coordinates 593147..593482 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS02860 (587684) 587684..588118 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW52_RS02865 (588136) 588136..589014 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW52_RS02870 (589004) 589004..589783 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW52_RS02875 (589794) 589794..590267 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW52_RS02880 (590290) 590290..591570 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW52_RS02885 (591819) 591819..592628 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDW52_RS02890 (592683) 592683..593147 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW52_RS02895 (593147) 593147..593482 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW52_RS02900 (593631) 593631..595202 - 1572 WP_001273741.1 galactarate dehydratase -
QDW52_RS02905 (595577) 595577..596911 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDW52_RS02910 (596927) 596927..597697 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T277324 WP_000347266.1 NZ_CP122617:c593147-592683 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277324 WP_001307405.1 NZ_CP122617:c593482-593147 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References