Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4935156..4935758 Replicon chromosome
Accession NZ_CP122604
Organism Escherichia coli strain ETEC6334

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW51_RS24355 Protein ID WP_000897305.1
Coordinates 4935447..4935758 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW51_RS24350 Protein ID WP_000356395.1
Coordinates 4935156..4935446 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW51_RS24315 (4930780) 4930780..4931682 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW51_RS24320 (4931679) 4931679..4932314 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW51_RS24325 (4932311) 4932311..4933240 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW51_RS24330 (4933422) 4933422..4933664 - 243 WP_001306649.1 protein YiiF -
QDW51_RS24335 (4933883) 4933883..4934101 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW51_RS24340 (4934520) 4934520..4934798 - 279 WP_001306650.1 hypothetical protein -
QDW51_RS24345 (4934850) 4934850..4935071 - 222 WP_001550354.1 hypothetical protein -
QDW51_RS24350 (4935156) 4935156..4935446 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW51_RS24355 (4935447) 4935447..4935758 - 312 WP_000897305.1 hypothetical protein Toxin
QDW51_RS24360 (4935987) 4935987..4936895 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW51_RS24365 (4937064) 4937064..4937978 - 915 WP_225102955.1 transposase -
QDW51_RS24370 (4937991) 4937991..4938878 - 888 Protein_4766 hypothetical protein -
QDW51_RS24375 (4939294) 4939294..4940235 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW51_RS24380 (4940280) 4940280..4940717 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277319 WP_000897305.1 NZ_CP122604:c4935758-4935447 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277319 WP_000356395.1 NZ_CP122604:c4935446-4935156 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References