Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1120542..1121269 Replicon chromosome
Accession NZ_CP122604
Organism Escherichia coli strain ETEC6334

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW51_RS05350 Protein ID WP_000547555.1
Coordinates 1120542..1120853 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW51_RS05355 Protein ID WP_000126294.1
Coordinates 1120850..1121269 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW51_RS05325 (1116477) 1116477..1118186 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW51_RS05330 (1118196) 1118196..1118738 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW51_RS05335 (1118738) 1118738..1119505 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW51_RS05340 (1119502) 1119502..1119912 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW51_RS05345 (1119905) 1119905..1120375 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW51_RS05350 (1120542) 1120542..1120853 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW51_RS05355 (1120850) 1120850..1121269 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW51_RS05360 (1121348) 1121348..1122772 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW51_RS05365 (1122781) 1122781..1124238 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW51_RS05370 (1124498) 1124498..1125508 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW51_RS05375 (1125657) 1125657..1126184 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277298 WP_000547555.1 NZ_CP122604:1120542-1120853 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277298 WP_000126294.1 NZ_CP122604:1120850-1121269 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References