Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4935149..4935751 Replicon chromosome
Accession NZ_CP122600
Organism Escherichia coli strain ETEC6333

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDX83_RS24360 Protein ID WP_000897305.1
Coordinates 4935440..4935751 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX83_RS24355 Protein ID WP_000356395.1
Coordinates 4935149..4935439 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX83_RS24320 (4930773) 4930773..4931675 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDX83_RS24325 (4931672) 4931672..4932307 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDX83_RS24330 (4932304) 4932304..4933233 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDX83_RS24335 (4933415) 4933415..4933657 - 243 WP_001306649.1 protein YiiF -
QDX83_RS24340 (4933876) 4933876..4934094 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDX83_RS24345 (4934513) 4934513..4934791 - 279 WP_001306650.1 hypothetical protein -
QDX83_RS24350 (4934843) 4934843..4935064 - 222 WP_001550354.1 hypothetical protein -
QDX83_RS24355 (4935149) 4935149..4935439 - 291 WP_000356395.1 NadS family protein Antitoxin
QDX83_RS24360 (4935440) 4935440..4935751 - 312 WP_000897305.1 hypothetical protein Toxin
QDX83_RS24365 (4935980) 4935980..4936888 + 909 WP_001306651.1 alpha/beta hydrolase -
QDX83_RS24370 (4937057) 4937057..4937971 - 915 WP_225102955.1 transposase -
QDX83_RS24375 (4937984) 4937984..4938871 - 888 Protein_4767 hypothetical protein -
QDX83_RS24380 (4939287) 4939287..4940228 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDX83_RS24385 (4940273) 4940273..4940710 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277294 WP_000897305.1 NZ_CP122600:c4935751-4935440 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277294 WP_000356395.1 NZ_CP122600:c4935439-4935149 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References