Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1120530..1121257 Replicon chromosome
Accession NZ_CP122600
Organism Escherichia coli strain ETEC6333

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDX83_RS05350 Protein ID WP_000547555.1
Coordinates 1120530..1120841 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX83_RS05355 Protein ID WP_000126294.1
Coordinates 1120838..1121257 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX83_RS05325 (1116465) 1116465..1118174 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDX83_RS05330 (1118184) 1118184..1118726 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDX83_RS05335 (1118726) 1118726..1119493 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDX83_RS05340 (1119490) 1119490..1119900 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDX83_RS05345 (1119893) 1119893..1120363 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDX83_RS05350 (1120530) 1120530..1120841 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDX83_RS05355 (1120838) 1120838..1121257 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDX83_RS05360 (1121336) 1121336..1122760 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDX83_RS05365 (1122769) 1122769..1124226 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDX83_RS05370 (1124486) 1124486..1125496 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDX83_RS05375 (1125645) 1125645..1126172 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277273 WP_000547555.1 NZ_CP122600:1120530-1120841 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277273 WP_000126294.1 NZ_CP122600:1120838-1121257 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References