Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 70475..71186 Replicon plasmid unnamed5
Accession NZ_CP122593
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name higB Uniprot ID I2UJZ0
Locus tag QDY30_RS26815 Protein ID WP_000162415.1
Coordinates 70475..70777 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDY30_RS26820 Protein ID WP_000806445.1
Coordinates 70848..71186 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS26785 (QDY30_26785) 65494..66144 - 651 WP_032153356.1 hypothetical protein -
QDY30_RS26790 (QDY30_26790) 66158..67063 - 906 WP_001258014.1 recombination-associated protein RdgC -
QDY30_RS26795 (QDY30_26795) 67123..67776 - 654 WP_000828873.1 hypothetical protein -
QDY30_RS26800 (QDY30_26800) 67773..68753 - 981 WP_000046499.1 hypothetical protein -
QDY30_RS26805 (QDY30_26805) 68757..69524 - 768 WP_000203290.1 hypothetical protein -
QDY30_RS26810 (QDY30_26810) 69521..70312 - 792 WP_000532305.1 hypothetical protein -
QDY30_RS26815 (QDY30_26815) 70475..70777 + 303 WP_000162415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY30_RS26820 (QDY30_26820) 70848..71186 + 339 WP_000806445.1 HigA family addiction module antitoxin Antitoxin
QDY30_RS26825 (QDY30_26825) 71243..71428 + 186 Protein_71 hypothetical protein -
QDY30_RS26830 (QDY30_26830) 71465..72193 + 729 WP_000986754.1 hypothetical protein -
QDY30_RS26835 (QDY30_26835) 72227..73420 - 1194 WP_001112633.1 hypothetical protein -
QDY30_RS26840 (QDY30_26840) 73413..73742 - 330 WP_000542383.1 hypothetical protein -
QDY30_RS26845 (QDY30_26845) 74071..74724 - 654 WP_000410952.1 hypothetical protein -
QDY30_RS26850 (QDY30_26850) 75071..75892 + 822 WP_001427910.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95838 95838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11818.56 Da        Isoelectric Point: 9.8739

>T277266 WP_000162415.1 NZ_CP122593:70475-70777 [Escherichia coli]
MTKKINIKDFRDAWLDDFFEFSTPHRKIPPDIHMTLSRKLDIINAATTCKDLRSPPGNRYEELSGKLNGYSSVRVNKQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13049.98 Da        Isoelectric Point: 6.4754

>AT277266 WP_000806445.1 NZ_CP122593:70848-71186 [Escherichia coli]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRINTAEKFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A631VBQ3

Antitoxin

Source ID Structure

References