Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3997258..3997799 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag QDY30_RS19515 Protein ID WP_000615980.1
Coordinates 3997521..3997799 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag QDY30_RS19510 Protein ID WP_000729709.1
Coordinates 3997258..3997518 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS19490 (3992964) 3992964..3993749 - 786 WP_086217936.1 putative lateral flagellar export/assembly protein LafU -
QDY30_RS19495 (3993721) 3993721..3995433 + 1713 Protein_3823 flagellar biosynthesis protein FlhA -
QDY30_RS19500 (3995626) 3995626..3996123 - 498 WP_086217930.1 REP-associated tyrosine transposase RayT -
QDY30_RS19505 (3996299) 3996299..3997072 - 774 WP_123007404.1 C40 family peptidase -
QDY30_RS19510 (3997258) 3997258..3997518 + 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDY30_RS19515 (3997521) 3997521..3997799 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDY30_RS19520 (3997955) 3997955..3998695 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDY30_RS19525 (3998666) 3998666..3999433 - 768 WP_000333379.1 class II glutamine amidotransferase -
QDY30_RS19530 (3999639) 3999639..4000217 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T277250 WP_000615980.1 NZ_CP122588:3997521-3997799 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT277250 WP_000729709.1 NZ_CP122588:3997258-3997518 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References