Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 641693..642492 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name yhaV Uniprot ID A0A161R7C1
Locus tag QDY30_RS03095 Protein ID WP_000347278.1
Coordinates 641693..642157 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDY30_RS03100 Protein ID WP_001307405.1
Coordinates 642157..642492 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS03065 (636694) 636694..637128 - 435 WP_028132083.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDY30_RS03070 (637146) 637146..638024 - 879 WP_086259429.1 PTS N-acetylgalactosamine transporter subunit IID -
QDY30_RS03075 (638014) 638014..638793 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDY30_RS03080 (638804) 638804..639277 - 474 WP_001626031.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDY30_RS03085 (639300) 639300..640580 - 1281 WP_086259428.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDY30_RS03090 (640829) 640829..641638 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDY30_RS03095 (641693) 641693..642157 - 465 WP_000347278.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDY30_RS03100 (642157) 642157..642492 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDY30_RS03105 (642641) 642641..644212 - 1572 WP_086259427.1 galactarate dehydratase -
QDY30_RS03110 (644587) 644587..645921 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDY30_RS03115 (645937) 645937..646707 + 771 WP_282866108.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17866.28 Da        Isoelectric Point: 9.6924

>T277234 WP_000347278.1 NZ_CP122588:c642157-641693 [Escherichia coli]
MDFPQRVNGWALYTHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277234 WP_001307405.1 NZ_CP122588:c642492-642157 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161R7C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References