Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 736317..737092 Replicon chromosome
Accession NZ_CP122587
Organism Klebsiella pneumoniae strain NCRE-61

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QDV36_RS07870 Protein ID WP_004150910.1
Coordinates 736607..737092 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QDV36_RS07865 Protein ID WP_004150912.1
Coordinates 736317..736610 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV36_RS07845 (QDV36_07840) 731524..732126 - 603 WP_002916735.1 short chain dehydrogenase -
QDV36_RS07850 (QDV36_07845) 732224..733136 + 913 Protein_719 LysR family transcriptional regulator -
QDV36_RS07855 (QDV36_07850) 733137..734285 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QDV36_RS07860 (QDV36_07855) 734296..735672 - 1377 WP_004217775.1 cystathionine beta-synthase -
QDV36_RS07865 (QDV36_07860) 736317..736610 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QDV36_RS07870 (QDV36_07865) 736607..737092 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QDV36_RS07875 (QDV36_07870) 737796..738389 + 594 WP_004188553.1 hypothetical protein -
QDV36_RS07880 (QDV36_07875) 738486..738702 + 217 Protein_725 transposase -
QDV36_RS07885 (QDV36_07880) 739308..740180 + 873 WP_004188557.1 ParA family protein -
QDV36_RS07890 (QDV36_07885) 740180..740563 + 384 WP_004150906.1 hypothetical protein -
QDV36_RS07895 (QDV36_07890) 740556..741923 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 738486..738638 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T277221 WP_004150910.1 NZ_CP122587:736607-737092 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT277221 WP_004150912.1 NZ_CP122587:736317-736610 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References