Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 732669..733444 Replicon chromosome
Accession NZ_CP122578
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag QDV38_RS06500 Protein ID WP_004889762.1
Coordinates 732959..733444 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QDV38_RS06495 Protein ID WP_004150912.1
Coordinates 732669..732962 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS06475 (727878) 727878..728480 - 603 WP_002916735.1 short chain dehydrogenase -
QDV38_RS06480 (728578) 728578..729489 + 912 WP_014906929.1 LysR family transcriptional regulator -
QDV38_RS06485 (729490) 729490..730638 - 1149 WP_014906930.1 PLP-dependent aspartate aminotransferase family protein -
QDV38_RS06490 (730649) 730649..732025 - 1377 WP_014906931.1 pyridoxal-phosphate dependent enzyme -
QDV38_RS06495 (732669) 732669..732962 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QDV38_RS06500 (732959) 732959..733444 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
QDV38_RS06505 (734148) 734148..734741 + 594 WP_004188553.1 hypothetical protein -
QDV38_RS06510 (734838) 734838..735054 + 217 Protein_715 transposase -
QDV38_RS06520 (735732) 735732..736445 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 734838..734990 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T277201 WP_004889762.1 NZ_CP122578:732959-733444 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT277201 WP_004150912.1 NZ_CP122578:732669-732962 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References