Detailed information of TA system TA027716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 4910345..4910850
• Replicon: chromosome
• Accession: NC_017770
• Organism: Solitalea canadensis DSM 3403

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: H8KLR0
• Locus tag: SOLCA_RS20700
• Protein ID: WP_014682436.1
• Coordinates: 4910593..4910850 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: H8KLQ9
• Locus tag: SOLCA_RS20695
• Protein ID: WP_014682435.1
• Coordinates: 4910345..4910602 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SOLCA_RS20675	4906406..4908031	+	1626	WP_014682431.1	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase	-
SOLCA_RS20680	4908234..4908953	+	720	WP_014682432.1	alpha/beta hydrolase	-
SOLCA_RS20685	4908955..4909428	-	474	WP_042480306.1	hypothetical protein	-
SOLCA_RS20690	4909523..4910266	+	744	WP_014682434.1	SLATT domain-containing protein	-
SOLCA_RS20695	4910345..4910602	+	258	WP_014682435.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SOLCA_RS20700	4910593..4910850	+	258	WP_014682436.1	Txe/YoeB family addiction module toxin	Toxin
SOLCA_RS20705	4910900..4912444	-	1545	WP_014682437.1	aldehyde dehydrogenase family protein	-
SOLCA_RS20710	4912818..4913270	+	453	WP_014682438.1	low molecular weight phosphotyrosine protein phosphatase	-
SOLCA_RS20715	4913282..4914652	+	1371	WP_157604780.1	histidine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10021.72 Da
• Isoelectric Point: 9.4308

>T27716 WP_014682436.1 NC_017770:4910593-4910850 [Solitalea canadensis DSM 3403]
MEVVFSEKAIEDLCFWKESNNIKAQEKITQLIKSFMESPFKGIGKPEPLKYGLAGYWSRRITAEHRLVYKVDNDKLIIIA
LRFHY

Nucleotide

• Length: 258 bp

>T27716 NC_017770:4910593-4910850 [Solitalea canadensis DSM 3403]
ATGGAAGTAGTTTTTTCGGAAAAAGCTATTGAAGATTTGTGCTTCTGGAAAGAGTCTAATAACATAAAAGCGCAAGAAAA
AATAACTCAATTGATAAAATCCTTTATGGAAAGCCCTTTTAAGGGGATTGGGAAACCTGAGCCGTTAAAATATGGACTTG
CCGGTTATTGGAGCCGTAGAATTACAGCGGAGCACCGATTAGTTTACAAAGTTGACAATGATAAACTGATAATCATTGCA
CTTCGATTTCATTATTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.07 Da
• Isoelectric Point: 5.1585

>AT27716 WP_014682435.1 NC_017770:4910345-4910602 [Solitalea canadensis DSM 3403]
MKVINYSDLRENLKSNLDYALEDEVTVKRPKGKGNVVILSEENYTSIMETLHLVSTEANRKHLIESIKQVEEGKVTSISV
DDLWK

Nucleotide

• Length: 258 bp

>AT27716 NC_017770:4910345-4910602 [Solitalea canadensis DSM 3403]
ATGAAAGTCATTAATTATTCTGATCTACGAGAAAACCTCAAATCAAATCTAGATTATGCTCTTGAAGATGAAGTGACTGT
TAAGCGTCCAAAAGGAAAAGGTAATGTAGTTATATTATCAGAAGAAAATTATACATCTATTATGGAGACCTTACATTTAG
TTTCAACAGAAGCAAATAGAAAACATTTGATCGAAAGTATTAAACAGGTTGAAGAAGGAAAAGTTACTTCAATTAGTGTT
GATGATTTATGGAAGTAG

Structures

Toxin

• AlphaFold DB: H8KLR0

Antitoxin

• AlphaFold DB: H8KLQ9