Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4554026..4554628 Replicon chromosome
Accession NZ_CP122517
Organism Escherichia coli strain MY1-8

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QCL60_RS21900 Protein ID WP_000897305.1
Coordinates 4554317..4554628 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QCL60_RS21895 Protein ID WP_000356397.1
Coordinates 4554026..4554316 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL60_RS21870 (4549951) 4549951..4550853 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QCL60_RS21875 (4550850) 4550850..4551485 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QCL60_RS21880 (4551482) 4551482..4552411 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QCL60_RS21885 (4552741) 4552741..4552983 - 243 WP_001087409.1 protein YiiF -
QCL60_RS21890 (4553203) 4553203..4553421 - 219 WP_001315930.1 CopG family transcriptional regulator -
QCL60_RS21895 (4554026) 4554026..4554316 - 291 WP_000356397.1 NadS family protein Antitoxin
QCL60_RS21900 (4554317) 4554317..4554628 - 312 WP_000897305.1 hypothetical protein Toxin
QCL60_RS21905 (4554857) 4554857..4555765 + 909 WP_001162704.1 alpha/beta hydrolase -
QCL60_RS21910 (4555829) 4555829..4556770 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QCL60_RS21915 (4556815) 4556815..4557252 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QCL60_RS21920 (4557249) 4557249..4558121 - 873 WP_000920762.1 virulence factor BrkB family protein -
QCL60_RS21925 (4558115) 4558115..4558714 - 600 WP_001295269.1 glucose-1-phosphatase -
QCL60_RS21930 (4558813) 4558813..4559598 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277154 WP_000897305.1 NZ_CP122517:c4554628-4554317 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT277154 WP_000356397.1 NZ_CP122517:c4554316-4554026 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References