Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 601587..602386 Replicon chromosome
Accession NZ_CP122517
Organism Escherichia coli strain MY1-8

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag QCL60_RS02940 Protein ID WP_000347266.1
Coordinates 601587..602051 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QCL60_RS02945 Protein ID WP_001307405.1
Coordinates 602051..602386 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL60_RS02910 (596588) 596588..597022 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QCL60_RS02915 (597040) 597040..597918 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
QCL60_RS02920 (597908) 597908..598687 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QCL60_RS02925 (598698) 598698..599171 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QCL60_RS02930 (599194) 599194..600474 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
QCL60_RS02935 (600723) 600723..601532 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QCL60_RS02940 (601587) 601587..602051 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QCL60_RS02945 (602051) 602051..602386 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QCL60_RS02950 (602535) 602535..604106 - 1572 WP_001273741.1 galactarate dehydratase -
QCL60_RS02960 (605258) 605258..606592 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QCL60_RS02965 (606608) 606608..607378 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 601587..615430 13843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T277137 WP_000347266.1 NZ_CP122517:c602051-601587 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277137 WP_001307405.1 NZ_CP122517:c602386-602051 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References