277099

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 751246..751939 Replicon chromosome
Accession NZ_CP122507
Organism Escherichia coli strain W444

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QC806_RS03690 Protein ID WP_000415584.1
Coordinates 751246..751542 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QC806_RS03695 Protein ID WP_000650107.1
Coordinates 751544..751939 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC806_RS03655 (746335) 746335..746649 - 315 WP_000958598.1 putative quinol monooxygenase -
QC806_RS03660 (746680) 746680..747261 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QC806_RS03665 (747580) 747580..747912 + 333 WP_000917684.1 DUF2645 family protein -
QC806_RS03670 (747958) 747958..749307 - 1350 WP_152914728.1 quorum sensing histidine kinase QseC -
QC806_RS03675 (749304) 749304..749963 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QC806_RS03680 (750115) 750115..750507 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QC806_RS03685 (750560) 750560..751041 + 482 Protein_722 GyrI-like domain-containing protein -
QC806_RS03690 (751246) 751246..751542 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QC806_RS03695 (751544) 751544..751939 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QC806_RS03700 (752072) 752072..753679 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QC806_RS03705 (753817) 753817..756075 + 2259 WP_088213288.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T277099 WP_000415584.1 NZ_CP122507:751246-751542 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT277099 WP_000650107.1 NZ_CP122507:751544-751939 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References