Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4670448..4671050 Replicon chromosome
Accession NZ_CP122503
Organism Escherichia coli strain W619

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QC808_RS22315 Protein ID WP_000897305.1
Coordinates 4670739..4671050 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QC808_RS22310 Protein ID WP_000356397.1
Coordinates 4670448..4670738 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC808_RS22285 (4666392) 4666392..4667294 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QC808_RS22290 (4667291) 4667291..4667926 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QC808_RS22295 (4667923) 4667923..4668852 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QC808_RS22300 (4669182) 4669182..4669424 - 243 WP_001087409.1 protein YiiF -
QC808_RS22305 (4669644) 4669644..4669862 - 219 WP_001315930.1 CopG family transcriptional regulator -
QC808_RS22310 (4670448) 4670448..4670738 - 291 WP_000356397.1 NadS family protein Antitoxin
QC808_RS22315 (4670739) 4670739..4671050 - 312 WP_000897305.1 hypothetical protein Toxin
QC808_RS22320 (4671279) 4671279..4672187 + 909 WP_001162704.1 alpha/beta hydrolase -
QC808_RS22325 (4672251) 4672251..4673192 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QC808_RS22330 (4673237) 4673237..4673674 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QC808_RS22335 (4673671) 4673671..4674543 - 873 WP_000920762.1 virulence factor BrkB family protein -
QC808_RS22340 (4674537) 4674537..4675136 - 600 WP_001295269.1 glucose-1-phosphatase -
QC808_RS22345 (4675235) 4675235..4676020 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277089 WP_000897305.1 NZ_CP122503:c4671050-4670739 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT277089 WP_000356397.1 NZ_CP122503:c4670738-4670448 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References