Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3846594..3847135 Replicon chromosome
Accession NZ_CP122503
Organism Escherichia coli strain W619

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag QC808_RS18525 Protein ID WP_000615980.1
Coordinates 3846857..3847135 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag QC808_RS18520 Protein ID WP_000729709.1
Coordinates 3846594..3846854 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC808_RS18505 (3842676) 3842676..3844769 + 2094 WP_021556448.1 flagellar biosynthesis protein FlhA -
QC808_RS18510 (3844962) 3844962..3845459 - 498 WP_021556447.1 REP-associated tyrosine transposase RayT -
QC808_RS18515 (3845635) 3845635..3846384 - 750 WP_000056850.1 C40 family peptidase -
QC808_RS18520 (3846594) 3846594..3846854 + 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QC808_RS18525 (3846857) 3846857..3847135 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QC808_RS18530 (3847291) 3847291..3848031 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QC808_RS18535 (3848002) 3848002..3848769 - 768 WP_000333379.1 class II glutamine amidotransferase -
QC808_RS18540 (3848975) 3848975..3849553 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3845635..3855387 9752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T277085 WP_000615980.1 NZ_CP122503:3846857-3847135 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT277085 WP_000729709.1 NZ_CP122503:3846594-3846854 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References