27707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2546142..2546665 Replicon chromosome
Accession NC_017763
Organism Staphylococcus aureus subsp. aureus HO 5096 0412

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SAEMRSA15_RS12990 Protein ID WP_000074048.1
Coordinates 2546142..2546408 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag SAEMRSA15_RS12995 Protein ID WP_000587616.1
Coordinates 2546408..2546665 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAEMRSA15_RS12965 2541353..2542540 - 1188 WP_000026196.1 MFS transporter -
SAEMRSA15_RS12970 2542934..2543710 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
SAEMRSA15_RS12975 2543703..2544365 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
SAEMRSA15_RS12980 2544711..2545787 - 1077 WP_001076688.1 M42 family metallopeptidase -
SAEMRSA15_RS12990 2546142..2546408 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SAEMRSA15_RS12995 2546408..2546665 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAEMRSA15_RS13000 2547024..2547479 + 456 WP_000732088.1 DUF1307 domain-containing protein -
SAEMRSA15_RS13005 2547647..2549224 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
SAEMRSA15_RS13010 2549419..2550168 + 750 WP_000072439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T27707 WP_000074048.1 NC_017763:c2546408-2546142 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T27707 NC_017763:c2546408-2546142 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT27707 WP_000587616.1 NC_017763:c2546665-2546408 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT27707 NC_017763:c2546665-2546408 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References