Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2488135..2488652 | Replicon | chromosome |
| Accession | NC_017763 | ||
| Organism | Staphylococcus aureus subsp. aureus HO 5096 0412 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | SAEMRSA15_RS12670 | Protein ID | WP_000113261.1 |
| Coordinates | 2488135..2488401 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | SAEMRSA15_RS12675 | Protein ID | WP_000584499.1 |
| Coordinates | 2488401..2488652 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAEMRSA15_RS12645 | 2483572..2484108 | - | 537 | WP_000169319.1 | GNAT family N-acetyltransferase | - |
| SAEMRSA15_RS12650 | 2484342..2485166 | - | 825 | WP_000594637.1 | formate/nitrite transporter family protein | - |
| SAEMRSA15_RS12655 | 2485369..2485551 | - | 183 | WP_000250735.1 | hypothetical protein | - |
| SAEMRSA15_RS12660 | 2485638..2486105 | - | 468 | WP_000153345.1 | SRPBCC domain-containing protein | - |
| SAEMRSA15_RS12665 | 2486291..2487841 | - | 1551 | WP_000727760.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| SAEMRSA15_RS12670 | 2488135..2488401 | - | 267 | WP_000113261.1 | Txe/YoeB family addiction module toxin | Toxin |
| SAEMRSA15_RS12675 | 2488401..2488652 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| SAEMRSA15_RS12680 | 2488815..2488916 | - | 102 | Protein_2401 | hypothetical protein | - |
| SAEMRSA15_RS12685 | 2488923..2489522 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| SAEMRSA15_RS12690 | 2489541..2489903 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| SAEMRSA15_RS12695 | 2490158..2491408 | + | 1251 | WP_001012231.1 | FemA/FemB family glycyltransferase FmhA | - |
| SAEMRSA15_RS12700 | 2491493..2492224 | - | 732 | WP_000615455.1 | amino acid ABC transporter ATP-binding protein | - |
| SAEMRSA15_RS12705 | 2492221..2492940 | - | 720 | WP_000479573.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10452.02 Da Isoelectric Point: 10.0373
>T27704 WP_000113261.1 NC_017763:c2488401-2488135 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY
Download Length: 267 bp
>T27704 NC_017763:c2488401-2488135 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT27704 WP_000584499.1 NC_017763:c2488652-2488401 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT27704 NC_017763:c2488652-2488401 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|