Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3616869..3617563 Replicon chromosome
Accession NZ_CP122496
Organism Escherichia coli strain a7

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag QC805_RS17955 Protein ID WP_001263493.1
Coordinates 3616869..3617267 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag QC805_RS17960 Protein ID WP_000554757.1
Coordinates 3617270..3617563 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3612529) 3612529..3612609 - 81 NuclAT_13 - -
- (3612529) 3612529..3612609 - 81 NuclAT_13 - -
- (3612529) 3612529..3612609 - 81 NuclAT_13 - -
- (3612529) 3612529..3612609 - 81 NuclAT_13 - -
QC805_RS17925 (3611869) 3611869..3613113 - 1245 WP_000189541.1 esterase FrsA -
QC805_RS17930 (3613205) 3613205..3613663 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QC805_RS17935 (3613924) 3613924..3615381 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
QC805_RS17940 (3615438) 3615438..3615959 - 522 Protein_3509 peptide chain release factor H -
QC805_RS17945 (3615958) 3615958..3616161 - 204 Protein_3510 RtcB family protein -
QC805_RS17950 (3616407) 3616407..3616859 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
QC805_RS17955 (3616869) 3616869..3617267 - 399 WP_001263493.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QC805_RS17960 (3617270) 3617270..3617563 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QC805_RS17965 (3617615) 3617615..3618670 - 1056 WP_001226164.1 DNA polymerase IV -
QC805_RS17970 (3618741) 3618741..3619526 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
QC805_RS17975 (3619498) 3619498..3621210 + 1713 Protein_3516 flagellar biosynthesis protein FlhA -
QC805_RS17980 (3621405) 3621405..3621932 - 528 WP_284613952.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T277037 WP_001263493.1 NZ_CP122496:c3617267-3616869 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT277037 WP_000554757.1 NZ_CP122496:c3617563-3617270 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EXB8

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References