Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 586985..587784 Replicon chromosome
Accession NZ_CP122496
Organism Escherichia coli strain a7

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QC805_RS02900 Protein ID WP_000347273.1
Coordinates 586985..587449 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QC805_RS02905 Protein ID WP_001307405.1
Coordinates 587449..587784 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC805_RS02870 (581986) 581986..582420 - 435 WP_000948842.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QC805_RS02875 (582438) 582438..583316 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QC805_RS02880 (583306) 583306..584085 - 780 WP_284614025.1 PTS N-acetylgalactosamine transporter subunit IIC -
QC805_RS02885 (584096) 584096..584569 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QC805_RS02890 (584592) 584592..585872 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QC805_RS02895 (586121) 586121..586930 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QC805_RS02900 (586985) 586985..587449 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QC805_RS02905 (587449) 587449..587784 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QC805_RS02910 (587933) 587933..589504 - 1572 WP_001273753.1 galactarate dehydratase -
QC805_RS02915 (589879) 589879..591213 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QC805_RS02920 (591229) 591229..591999 + 771 WP_284614026.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 576429..598659 22230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277026 WP_000347273.1 NZ_CP122496:c587449-586985 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277026 WP_001307405.1 NZ_CP122496:c587784-587449 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References