Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3823765..3824306 Replicon chromosome
Accession NZ_CP122492
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QC807_RS18680 Protein ID WP_000615976.1
Coordinates 3824028..3824306 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QC807_RS18675 Protein ID WP_000729704.1
Coordinates 3823765..3824025 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS18650 (3818801) 3818801..3819940 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
QC807_RS18655 (3819924) 3819924..3822017 + 2094 WP_001597626.1 flagellar biosynthesis protein FlhA -
QC807_RS18660 (3822122) 3822122..3822400 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QC807_RS18665 (3822393) 3822393..3822749 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QC807_RS18670 (3822806) 3822806..3823579 - 774 WP_000543897.1 C40 family peptidase -
QC807_RS18675 (3823765) 3823765..3824025 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QC807_RS18680 (3824028) 3824028..3824306 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QC807_RS18685 (3824462) 3824462..3825202 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QC807_RS18690 (3825173) 3825173..3825940 - 768 WP_000333380.1 class II glutamine amidotransferase -
QC807_RS18695 (3826146) 3826146..3826724 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T277009 WP_000615976.1 NZ_CP122492:3824028-3824306 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT277009 WP_000729704.1 NZ_CP122492:3823765-3824025 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References