Detailed information of TA system TA027699

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF2/-
• Location: 2048493..2048792
• Replicon: chromosome
• Accession: NC_017763
• Organism: Staphylococcus aureus subsp. aureus HO 5096 0412

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAEMRSA15_RS14870
• Protein ID: WP_011447039.1
• Coordinates: 2048616..2048792 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2048493..2048548 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAEMRSA15_RS10250	2043824..2044084	+	261	WP_001791826.1	hypothetical protein	-
SAEMRSA15_RS10255	2044137..2044487	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAEMRSA15_RS10260	2045172..2045621	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAEMRSA15_RS15250	2045716..2046051	-	336	Protein_1934	SH3 domain-containing protein	-
SAEMRSA15_RS10270	2046701..2047192	-	492	WP_000919349.1	staphylokinase	-
SAEMRSA15_RS10275	2047383..2048138	-	756	WP_000861039.1	CHAP domain-containing protein	-
SAEMRSA15_RS10280	2048150..2048404	-	255	WP_000611512.1	phage holin	-
SAEMRSA15_RS14865	2048456..2048563	+	108	WP_001791821.1	hypothetical protein	-
-	2048485..2048624	+	140	NuclAT_1	-	-
-	2048485..2048624	+	140	NuclAT_1	-	-
-	2048485..2048624	+	140	NuclAT_1	-	-
-	2048485..2048624	+	140	NuclAT_1	-	-
-	2048493..2048548	+	56	-	-	Antitoxin
SAEMRSA15_RS14870	2048616..2048792	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAEMRSA15_RS10290	2048942..2049238	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAEMRSA15_RS10295	2049296..2049583	-	288	WP_001040261.1	hypothetical protein	-
SAEMRSA15_RS10300	2049630..2049782	-	153	WP_001153681.1	hypothetical protein	-
SAEMRSA15_RS10305	2049772..2053557	-	3786	WP_000582168.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2044137..2105082	60945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T27699 WP_011447039.1 NC_017763:c2048792-2048616 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T27699 NC_017763:c2048792-2048616 [Staphylococcus aureus subsp. aureus HO 5096 0412]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT27699 NC_017763:2048493-2048548 [Staphylococcus aureus subsp. aureus HO 5096 0412]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin