Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 356138..356778 Replicon chromosome
Accession NZ_CP122469
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_BC16

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag P9M40_RS01650 Protein ID WP_016529833.1
Coordinates 356138..356485 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P9M40_RS01655 Protein ID WP_040181955.1
Coordinates 356485..356778 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M40_RS01640 (352064) 352064..353497 + 1434 WP_002920564.1 glycogen synthase GlgA -
P9M40_RS01645 (353515) 353515..355962 + 2448 WP_002920561.1 glycogen phosphorylase -
P9M40_RS01650 (356138) 356138..356485 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9M40_RS01655 (356485) 356485..356778 + 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
P9M40_RS01660 (356848) 356848..358356 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
P9M40_RS01665 (358561) 358561..358890 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
P9M40_RS01670 (358941) 358941..359771 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
P9M40_RS01675 (359821) 359821..360579 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T276978 WP_016529833.1 NZ_CP122469:356138-356485 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT276978 WP_040181955.1 NZ_CP122469:356485-356778 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References