Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4582703..4583457 | Replicon | chromosome |
Accession | NZ_CP122457 | ||
Organism | Salmonella enterica subsp. enterica strain TZ282 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | QCX26_RS21950 | Protein ID | WP_000558162.1 |
Coordinates | 4582703..4583014 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | QCX26_RS21955 | Protein ID | WP_001259009.1 |
Coordinates | 4583011..4583457 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QCX26_RS21920 (4578369) | 4578369..4579271 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
QCX26_RS21925 (4579268) | 4579268..4579903 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
QCX26_RS21930 (4579900) | 4579900..4580829 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
QCX26_RS21935 (4580867) | 4580867..4581241 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
QCX26_RS21940 (4581241) | 4581241..4581483 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
QCX26_RS21945 (4581688) | 4581688..4582617 | + | 930 | WP_023234201.1 | alpha/beta hydrolase | - |
QCX26_RS21950 (4582703) | 4582703..4583014 | + | 312 | WP_000558162.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
QCX26_RS21955 (4583011) | 4583011..4583457 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
QCX26_RS21960 (4583472) | 4583472..4584413 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
QCX26_RS21965 (4584458) | 4584458..4584895 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
QCX26_RS21970 (4584892) | 4584892..4585764 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
QCX26_RS21975 (4585758) | 4585758..4586357 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
QCX26_RS21980 (4586548) | 4586548..4587351 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
QCX26_RS21985 (4587385) | 4587385..4588281 | - | 897 | WP_283880386.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12358.28 Da Isoelectric Point: 9.3143
>T276959 WP_000558162.1 NZ_CP122457:4582703-4583014 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT276959 WP_001259009.1 NZ_CP122457:4583011-4583457 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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