Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4703644..4704443 Replicon chromosome
Accession NZ_CP122454
Organism Escherichia coli strain 82.0311

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag QBY76_RS22830 Protein ID WP_087598199.1
Coordinates 4703979..4704443 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag QBY76_RS22825 Protein ID WP_087598198.1
Coordinates 4703644..4703979 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY76_RS22810 (4699429) 4699429..4700199 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QBY76_RS22815 (4700215) 4700215..4701549 - 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
QBY76_RS22820 (4701924) 4701924..4703495 + 1572 WP_001273940.1 galactarate dehydratase -
QBY76_RS22825 (4703644) 4703644..4703979 + 336 WP_087598198.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QBY76_RS22830 (4703979) 4703979..4704443 + 465 WP_087598199.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QBY76_RS22835 (4704498) 4704498..4705307 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QBY76_RS22840 (4705556) 4705556..4706836 + 1281 WP_052925113.1 tagatose-bisphosphate aldolase subunit KbaZ -
QBY76_RS22845 (4706859) 4706859..4707332 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QBY76_RS22850 (4707343) 4707343..4708122 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QBY76_RS22855 (4708112) 4708112..4708990 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QBY76_RS22860 (4709008) 4709008..4709442 + 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17811.16 Da        Isoelectric Point: 9.4947

>T276938 WP_087598199.1 NZ_CP122454:4703979-4704443 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDAFVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12303.88 Da        Isoelectric Point: 4.5392

>AT276938 WP_087598198.1 NZ_CP122454:4703644-4703979 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFLCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References