Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3430395..3430897 Replicon chromosome
Accession NZ_CP122454
Organism Escherichia coli strain 82.0311

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QBY76_RS16925 Protein ID WP_000767822.1
Coordinates 3430395..3430649 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QBY76_RS16930 Protein ID WP_001259255.1
Coordinates 3430646..3430897 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY76_RS16905 (3426888) 3426888..3428246 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QBY76_RS16910 (3428236) 3428236..3428298 - 63 WP_010723108.1 membrane protein YoeI -
QBY76_RS16915 (3428513) 3428513..3429442 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QBY76_RS16920 (3429488) 3429488..3430312 - 825 WP_000754733.1 SDR family oxidoreductase -
QBY76_RS16925 (3430395) 3430395..3430649 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QBY76_RS16930 (3430646) 3430646..3430897 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QBY76_RS16935 (3431180) 3431180..3431230 + 51 WP_001364200.1 his operon leader peptide -
QBY76_RS16940 (3431376) 3431376..3432275 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QBY76_RS16945 (3432281) 3432281..3433585 + 1305 WP_001297912.1 histidinol dehydrogenase -
QBY76_RS16950 (3433582) 3433582..3434652 + 1071 WP_000108995.1 histidinol-phosphate transaminase -
QBY76_RS16955 (3434652) 3434652..3435719 + 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T276933 WP_000767822.1 NZ_CP122454:c3430649-3430395 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT276933 WP_001259255.1 NZ_CP122454:c3430897-3430646 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References