Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2791464..2792026 Replicon chromosome
Accession NZ_CP122454
Organism Escherichia coli strain 82.0311

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag QBY76_RS13830 Protein ID WP_000605675.1
Coordinates 2791748..2792026 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag QBY76_RS13825 Protein ID WP_000781370.1
Coordinates 2791464..2791748 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY76_RS13810 (2786645) 2786645..2789692 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
QBY76_RS13815 (2789705) 2789705..2790589 + 885 WP_001240581.1 formate dehydrogenase N subunit beta -
QBY76_RS13820 (2790582) 2790582..2791235 + 654 WP_000045646.1 formate dehydrogenase-N subunit gamma -
QBY76_RS13825 (2791464) 2791464..2791748 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
QBY76_RS13830 (2791748) 2791748..2792026 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBY76_RS13835 (2792212) 2792212..2793222 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
QBY76_RS13840 (2793356) 2793356..2795053 - 1698 WP_000433462.1 malate dehydrogenase -
QBY76_RS13845 (2795209) 2795209..2795346 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
QBY76_RS13850 (2795448) 2795448..2795663 - 216 WP_000495766.1 biofilm-dependent modulation protein -
QBY76_RS13855 (2796009) 2796009..2796440 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T276926 WP_000605675.1 NZ_CP122454:c2792026-2791748 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT276926 WP_000781370.1 NZ_CP122454:c2791748-2791464 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References