Detailed information of TA system TA027692

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1560570..1561149
• Replicon: chromosome
• Accession: NC_017763
• Organism: Staphylococcus aureus subsp. aureus HO 5096 0412

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAEMRSA15_RS07585
• Protein ID: WP_001025401.1
• Coordinates: 1560904..1561149 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1560570..1560935 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAEMRSA15_RS07545	1557316..1557870	-	555	WP_000647288.1	DUF2815 family protein	-
SAEMRSA15_RS07550	1557896..1559062	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
SAEMRSA15_RS07555	1559059..1559421	-	363	WP_000985986.1	hypothetical protein	-
SAEMRSA15_RS07560	1559436..1559759	-	324	WP_000175000.1	hypothetical protein	-
SAEMRSA15_RS07565	1559838..1559999	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAEMRSA15_RS07570	1560012..1560275	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAEMRSA15_RS07575	1560300..1560515	-	216	WP_001097552.1	hypothetical protein	-
SAEMRSA15_RS07580	1560570..1560935	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAEMRSA15_RS07585	1560904..1561149	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAEMRSA15_RS07590	1561216..1561596	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
SAEMRSA15_RS07595	1561583..1561780	-	198	WP_001148860.1	hypothetical protein	-
SAEMRSA15_RS07600	1561850..1562062	+	213	WP_000362644.1	hypothetical protein	-
SAEMRSA15_RS15345	1562103..1562252	-	150	WP_000771849.1	hypothetical protein	-
SAEMRSA15_RS07605	1562267..1562710	-	444	WP_000435357.1	hypothetical protein	-
SAEMRSA15_RS07610	1562758..1562970	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
SAEMRSA15_RS07615	1563122..1563853	+	732	WP_000511090.1	XRE family transcriptional regulator	-
SAEMRSA15_RS07620	1563924..1564106	+	183	WP_000705240.1	hypothetical protein	-
SAEMRSA15_RS07625	1564143..1564289	+	147	WP_001795334.1	hypothetical protein	-
SAEMRSA15_RS07630	1564286..1564900	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1516430..1581203	64773

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T27692 WP_001025401.1 NC_017763:c1561149-1560904 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T27692 NC_017763:c1561149-1560904 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT27692 NC_017763:1560570-1560935 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin