Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1910829..1911331 Replicon chromosome
Accession NZ_CP122451
Organism Escherichia coli strain 82.0312

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QBY78_RS09085 Protein ID WP_000767822.1
Coordinates 1911077..1911331 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QBY78_RS09080 Protein ID WP_001259255.1
Coordinates 1910829..1911080 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY78_RS09055 (1906007) 1906007..1907074 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QBY78_RS09060 (1907074) 1907074..1908144 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
QBY78_RS09065 (1908141) 1908141..1909445 - 1305 WP_001297912.1 histidinol dehydrogenase -
QBY78_RS09070 (1909451) 1909451..1910350 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QBY78_RS09075 (1910496) 1910496..1910546 - 51 WP_001364200.1 his operon leader peptide -
QBY78_RS09080 (1910829) 1910829..1911080 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QBY78_RS09085 (1911077) 1911077..1911331 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QBY78_RS09090 (1911414) 1911414..1912238 + 825 WP_000754733.1 SDR family oxidoreductase -
QBY78_RS09095 (1912284) 1912284..1913213 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QBY78_RS09100 (1913428) 1913428..1913490 + 63 WP_010723108.1 membrane protein YoeI -
QBY78_RS09105 (1913480) 1913480..1914838 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T276901 WP_000767822.1 NZ_CP122451:1911077-1911331 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT276901 WP_001259255.1 NZ_CP122451:1910829-1911080 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References