Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1185070..1185797 Replicon chromosome
Accession NZ_CP122451
Organism Escherichia coli strain 82.0312

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag QBY78_RS05695 Protein ID WP_000547563.1
Coordinates 1185070..1185381 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QBY78_RS05700 Protein ID WP_000126304.1
Coordinates 1185378..1185797 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY78_RS05665 (1180214) 1180214..1181923 + 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -
QBY78_RS05670 (1181933) 1181933..1182475 + 543 WP_000493799.1 formate hydrogenlyase subunit HycF -
QBY78_RS05675 (1182475) 1182475..1183242 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QBY78_RS05680 (1183239) 1183239..1183649 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
QBY78_RS05685 (1183642) 1183642..1184109 + 468 WP_021522200.1 hydrogenase maturation peptidase HycI -
QBY78_RS05690 (1184152) 1184152..1184907 + 756 WP_001314074.1 hypothetical protein -
QBY78_RS05695 (1185070) 1185070..1185381 + 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
QBY78_RS05700 (1185378) 1185378..1185797 + 420 WP_000126304.1 helix-turn-helix domain-containing protein Antitoxin
QBY78_RS05705 (1185889) 1185889..1186317 - 429 WP_000536064.1 hypothetical protein -
QBY78_RS05710 (1186702) 1186702..1187229 + 528 WP_001078777.1 electron transport protein HydN -
QBY78_RS05715 (1187382) 1187382..1189634 + 2253 WP_085455499.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T276900 WP_000547563.1 NZ_CP122451:1185070-1185381 [Escherichia coli]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15474.50 Da        Isoelectric Point: 4.4596

>AT276900 WP_000126304.1 NZ_CP122451:1185378-1185797 [Escherichia coli]
MTANAVRAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References