Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4903273..4903875 Replicon chromosome
Accession NZ_CP122448
Organism Escherichia coli strain 85.0412

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QBY77_RS23620 Protein ID WP_000897305.1
Coordinates 4903564..4903875 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QBY77_RS23615 Protein ID WP_000356397.1
Coordinates 4903273..4903563 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY77_RS23595 (4899775) 4899775..4900677 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QBY77_RS23600 (4900674) 4900674..4901309 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QBY77_RS23605 (4901306) 4901306..4902235 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QBY77_RS23610 (4902450) 4902450..4902668 - 219 WP_001298592.1 CopG family transcriptional regulator -
QBY77_RS23615 (4903273) 4903273..4903563 - 291 WP_000356397.1 NadS family protein Antitoxin
QBY77_RS23620 (4903564) 4903564..4903875 - 312 WP_000897305.1 hypothetical protein Toxin
QBY77_RS23625 (4904104) 4904104..4905012 + 909 WP_001298596.1 alpha/beta hydrolase -
QBY77_RS23630 (4905076) 4905076..4906017 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QBY77_RS23635 (4906062) 4906062..4906499 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QBY77_RS23640 (4906496) 4906496..4907368 - 873 WP_000920762.1 virulence factor BrkB family protein -
QBY77_RS23645 (4907362) 4907362..4907961 - 600 WP_001298594.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12172.16 Da        Isoelectric Point: 9.7791

>T276891 WP_000897305.1 NZ_CP122448:c4903875-4903564 [Escherichia coli]
ILFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT276891 WP_000356397.1 NZ_CP122448:c4903563-4903273 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References