Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4294420..4294832 Replicon chromosome
Accession NZ_CP122448
Organism Escherichia coli strain 85.0412

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag QBY77_RS20790 Protein ID WP_000132614.1
Coordinates 4294491..4294832 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4294420..4294496 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY77_RS20780 (4291095) 4291095..4292564 + 1470 WP_001540814.1 type I restriction-modification system subunit M -
QBY77_RS20785 (4292564) 4292564..4294270 + 1707 WP_001100194.1 restriction endonuclease subunit S -
- (4294420) 4294420..4294496 - 77 NuclAT_6 - Antitoxin
- (4294420) 4294420..4294496 - 77 NuclAT_6 - Antitoxin
- (4294420) 4294420..4294496 - 77 NuclAT_6 - Antitoxin
- (4294420) 4294420..4294496 - 77 NuclAT_6 - Antitoxin
- (4294420) 4294420..4294496 - 77 NuclAT_7 - Antitoxin
- (4294420) 4294420..4294496 - 77 NuclAT_7 - Antitoxin
- (4294420) 4294420..4294496 - 77 NuclAT_7 - Antitoxin
- (4294420) 4294420..4294496 - 77 NuclAT_7 - Antitoxin
QBY77_RS20790 (4294491) 4294491..4294832 + 342 WP_000132614.1 endoribonuclease SymE Toxin
QBY77_RS20795 (4294879) 4294879..4296042 - 1164 WP_072002093.1 DUF1524 domain-containing protein -
QBY77_RS20800 (4296090) 4296090..4296972 - 883 Protein_4076 DUF262 domain-containing protein -
QBY77_RS20805 (4297162) 4297162..4297239 + 78 Protein_4077 hypothetical protein -
QBY77_RS20810 (4297378) 4297378..4298298 - 921 WP_000181195.1 Rpn family recombination-promoting nuclease/putative transposase -
QBY77_RS20815 (4298483) 4298483..4299763 + 1281 WP_001298033.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4278299..4297035 18736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T276885 WP_000132614.1 NZ_CP122448:4294491-4294832 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT276885 NZ_CP122448:c4294496-4294420 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References