Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2009290..2009792 Replicon chromosome
Accession NZ_CP122448
Organism Escherichia coli strain 85.0412

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QBY77_RS09615 Protein ID WP_000767822.1
Coordinates 2009538..2009792 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QBY77_RS09610 Protein ID WP_001259255.1
Coordinates 2009290..2009541 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY77_RS09585 (2004468) 2004468..2005535 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QBY77_RS09590 (2005535) 2005535..2006605 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
QBY77_RS09595 (2006602) 2006602..2007906 - 1305 WP_001297912.1 histidinol dehydrogenase -
QBY77_RS09600 (2007912) 2007912..2008811 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QBY77_RS09605 (2008957) 2008957..2009007 - 51 WP_001364200.1 his operon leader peptide -
QBY77_RS09610 (2009290) 2009290..2009541 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QBY77_RS09615 (2009538) 2009538..2009792 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QBY77_RS09620 (2009875) 2009875..2010699 + 825 WP_000754733.1 SDR family oxidoreductase -
QBY77_RS09625 (2010745) 2010745..2011674 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QBY77_RS09630 (2011889) 2011889..2011951 + 63 WP_010723108.1 membrane protein YoeI -
QBY77_RS09635 (2011941) 2011941..2013299 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T276871 WP_000767822.1 NZ_CP122448:2009538-2009792 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT276871 WP_001259255.1 NZ_CP122448:2009290-2009541 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References