Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 627783..628582 Replicon chromosome
Accession NZ_CP122448
Organism Escherichia coli strain 85.0412

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag QBY77_RS03105 Protein ID WP_000347252.1
Coordinates 627783..628247 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QBY77_RS03110 Protein ID WP_001296435.1
Coordinates 628247..628582 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY77_RS03075 (622784) 622784..623218 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QBY77_RS03080 (623236) 623236..624114 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
QBY77_RS03085 (624104) 624104..624883 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QBY77_RS03090 (624894) 624894..625367 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
QBY77_RS03095 (625390) 625390..626670 - 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
QBY77_RS03100 (626919) 626919..627728 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QBY77_RS03105 (627783) 627783..628247 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QBY77_RS03110 (628247) 628247..628582 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QBY77_RS03115 (628731) 628731..630302 - 1572 WP_001273939.1 galactarate dehydratase -
QBY77_RS03120 (630677) 630677..632011 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
QBY77_RS03125 (632027) 632027..632797 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T276867 WP_000347252.1 NZ_CP122448:c628247-627783 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT276867 WP_001296435.1 NZ_CP122448:c628582-628247 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References