Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1866447..1867174 Replicon chromosome
Accession NZ_CP122442
Organism Enterobacter ludwigii strain I9455333cz

Toxin (Protein)


Gene name higB Uniprot ID A0A663AUB1
Locus tag QCL67_RS09125 Protein ID WP_000558568.1
Coordinates 1866863..1867174 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V0AHC4
Locus tag QCL67_RS09120 Protein ID WP_000990392.1
Coordinates 1866447..1866866 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL67_RS09085 (QCL67_09085) 1862134..1862496 - 363 WP_000783215.1 arsenite efflux transporter metallochaperone ArsD -
QCL67_RS09090 (QCL67_09090) 1862544..1862897 - 354 WP_001114073.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
QCL67_RS09095 (QCL67_09095) 1863190..1863330 + 141 WP_004118614.1 hypothetical protein -
QCL67_RS09100 (QCL67_09100) 1863498..1863806 + 309 WP_020324596.1 Ref family recombination enhancement nuclease -
QCL67_RS09105 (QCL67_09105) 1864230..1864889 + 660 WP_182268586.1 maturation control protein -
QCL67_RS09110 (QCL67_09110) 1864886..1865215 + 330 WP_000121260.1 hypothetical protein -
QCL67_RS09115 (QCL67_09115) 1865208..1866410 + 1203 WP_000753105.1 hypothetical protein -
QCL67_RS09120 (QCL67_09120) 1866447..1866866 - 420 WP_000990392.1 helix-turn-helix domain-containing protein Antitoxin
QCL67_RS09125 (QCL67_09125) 1866863..1867174 - 312 WP_000558568.1 type II toxin-antitoxin system HigB family toxin Toxin
QCL67_RS09130 (QCL67_09130) 1867385..1867765 + 381 Protein_1791 gluconate permease -
QCL67_RS09135 (QCL67_09135) 1867815..1868510 - 696 WP_000370412.1 lactate utilization protein C -
QCL67_RS09140 (QCL67_09140) 1868503..1869930 - 1428 WP_000023895.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
QCL67_RS09145 (QCL67_09145) 1869941..1870660 - 720 WP_001102107.1 (Fe-S)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1805691..1871390 65699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12372.11 Da        Isoelectric Point: 10.0935

>T276855 WP_000558568.1 NZ_CP122442:c1867174-1866863 [Enterobacter ludwigii]
MHVVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15534.71 Da        Isoelectric Point: 4.4702

>AT276855 WP_000990392.1 NZ_CP122442:c1866866-1866447 [Enterobacter ludwigii]
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AUB1

Antitoxin

Source ID Structure
AlphaFold DB V0AHC4

References