Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3936673..3937303 Replicon chromosome
Accession NZ_CP122407
Organism Rugamonas sp. DEMB1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QC826_RS17920 Protein ID WP_279761814.1
Coordinates 3936673..3936954 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QC826_RS17925 Protein ID WP_093388625.1
Coordinates 3936974..3937303 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC826_RS17885 (QC826_17885) 3931789..3932061 - 273 WP_279761808.1 DUF5668 domain-containing protein -
QC826_RS17890 (QC826_17890) 3932351..3932512 - 162 WP_193616304.1 hypothetical protein -
QC826_RS17895 (QC826_17895) 3932686..3933567 - 882 WP_279761809.1 LysR family transcriptional regulator -
QC826_RS17900 (QC826_17900) 3933603..3934220 - 618 WP_279761810.1 hemolysin III family protein -
QC826_RS17905 (QC826_17905) 3934326..3934730 - 405 WP_279761811.1 hypothetical protein -
QC826_RS17910 (QC826_17910) 3934878..3935966 + 1089 WP_279761812.1 hypothetical protein -
QC826_RS17915 (QC826_17915) 3936112..3936540 + 429 WP_279761813.1 hypothetical protein -
QC826_RS17920 (QC826_17920) 3936673..3936954 + 282 WP_279761814.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QC826_RS17925 (QC826_17925) 3936974..3937303 + 330 WP_093388625.1 HigA family addiction module antitoxin Antitoxin
QC826_RS17930 (QC826_17930) 3937544..3938092 + 549 WP_279761815.1 FxDxF family PEP-CTERM protein -
QC826_RS17935 (QC826_17935) 3938391..3940160 + 1770 WP_279761816.1 methyl-accepting chemotaxis protein -
QC826_RS17940 (QC826_17940) 3940239..3940913 + 675 WP_279761817.1 adenylyl-sulfate kinase -
QC826_RS17945 (QC826_17945) 3940917..3941954 + 1038 WP_279761818.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10432.89 Da        Isoelectric Point: 9.6286

>T276846 WP_279761814.1 NZ_CP122407:3936673-3936954 [Rugamonas sp. DEMB1]
MTIRSFRCKDTKALYAGGKVGKFANVRSTAERKLQLLDSAASLDFLRTPPGNHLEALGADRKGQYSIRINNQFRICFVWT
SAGPEDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11996.77 Da        Isoelectric Point: 6.7273

>AT276846 WP_093388625.1 NZ_CP122407:3936974-3937303 [Rugamonas sp. DEMB1]
MAENQMRPIHPGEILREEFLAPLAMTPHALSKALHVTPARINDIVNEKRGVSADTALRLARYFGGEPQSWLNLQQAYDLK
MATRAGLERILVEVRPRAPGDGDEAALAA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References