Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2078183..2078793 Replicon chromosome
Accession NZ_CP122407
Organism Rugamonas sp. DEMB1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QC826_RS09665 Protein ID WP_279765396.1
Coordinates 2078515..2078793 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QC826_RS09660 Protein ID WP_279765395.1
Coordinates 2078183..2078491 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC826_RS09625 (QC826_09625) 2074164..2075060 - 897 WP_279765389.1 alpha/beta hydrolase -
QC826_RS09630 (QC826_09630) 2075149..2075586 - 438 WP_279765390.1 MarR family transcriptional regulator -
QC826_RS09635 (QC826_09635) 2075691..2076197 - 507 WP_279765391.1 carboxymuconolactone decarboxylase family protein -
QC826_RS09640 (QC826_09640) 2076262..2076747 + 486 WP_279765392.1 MarR family transcriptional regulator -
QC826_RS09645 (QC826_09645) 2076740..2077051 + 312 WP_093386726.1 Dabb family protein -
QC826_RS09650 (QC826_09650) 2077159..2077776 + 618 WP_279765393.1 2-hydroxychromene-2-carboxylate isomerase -
QC826_RS09655 (QC826_09655) 2077832..2078164 - 333 WP_279765394.1 hypothetical protein -
QC826_RS09660 (QC826_09660) 2078183..2078491 - 309 WP_279765395.1 HigA family addiction module antitoxin Antitoxin
QC826_RS09665 (QC826_09665) 2078515..2078793 - 279 WP_279765396.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QC826_RS09670 (QC826_09670) 2078963..2080225 - 1263 WP_279765397.1 D-amino acid dehydrogenase -
QC826_RS09675 (QC826_09675) 2080481..2080825 + 345 WP_093386711.1 zinc ribbon domain-containing protein YjdM -
QC826_RS09680 (QC826_09680) 2080931..2081846 - 916 Protein_1890 3-hydroxyisobutyrate dehydrogenase -
QC826_RS09685 (QC826_09685) 2081843..2083033 - 1191 WP_279765398.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10602.14 Da        Isoelectric Point: 9.2231

>T276842 WP_279765396.1 NZ_CP122407:c2078793-2078515 [Rugamonas sp. DEMB1]
MIISFACSETEALFNSLSVRHFKNIERSARRKLLQLNAAGELRSLRIPPGNMLEALSGSRKGQYSIRINDQWRICFKWQA
DGPHDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11718.54 Da        Isoelectric Point: 5.6920

>AT276842 WP_279765395.1 NZ_CP122407:c2078491-2078183 [Rugamonas sp. DEMB1]
MAKLLDEVHPGEILLEEFMRPLGITAQQLAADIDVSPSRISDIVHGNRPITADTALRLGLFFDMEARYWLNLQSEYDMRI
AQRTLKDQLAPRIRVYQPVRPT

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References