Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 794869..795644 Replicon chromosome
Accession NZ_CP122389
Organism Klebsiella pneumoniae strain KP9650

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QCB43_RS03975 Protein ID WP_004150910.1
Coordinates 795159..795644 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QCB43_RS03970 Protein ID WP_004150912.1
Coordinates 794869..795162 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCB43_RS03950 (QCB43_03950) 790077..790679 - 603 WP_004174410.1 short chain dehydrogenase -
QCB43_RS03955 (QCB43_03955) 790777..791688 + 912 WP_004181308.1 LysR family transcriptional regulator -
QCB43_RS03960 (QCB43_03960) 791689..792837 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
QCB43_RS03965 (QCB43_03965) 792848..794224 - 1377 WP_023301305.1 pyridoxal-phosphate dependent enzyme -
QCB43_RS03970 (QCB43_03970) 794869..795162 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QCB43_RS03975 (QCB43_03975) 795159..795644 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QCB43_RS03980 (QCB43_03980) 796348..796941 + 594 WP_004188553.1 hypothetical protein -
QCB43_RS03985 (QCB43_03985) 797038..797254 + 217 Protein_784 transposase -
QCB43_RS03990 (QCB43_03990) 797861..798733 + 873 WP_004188557.1 ParA family protein -
QCB43_RS03995 (QCB43_03995) 798733..799116 + 384 WP_004150906.1 hypothetical protein -
QCB43_RS04000 (QCB43_04000) 799109..800476 + 1368 WP_023301304.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 797038..797190 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T276814 WP_004150910.1 NZ_CP122389:795159-795644 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT276814 WP_004150912.1 NZ_CP122389:794869-795162 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References