Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3880065..3880717 Replicon chromosome
Accession NZ_CP122328
Organism Pantoea agglomerans pv. betae strain 4188

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A7P61_RS22530 Protein ID WP_064704967.1
Coordinates 3880065..3880418 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8X8DRN0
Locus tag A7P61_RS22535 Protein ID WP_010252120.1
Coordinates 3880418..3880717 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P61_RS22515 (A7P61_22515) 3875791..3877575 - 1785 WP_010252112.1 GMC family oxidoreductase -
A7P61_RS22520 (A7P61_22520) 3877578..3878312 - 735 WP_033787533.1 gluconate 2-dehydrogenase subunit 3 family protein -
A7P61_RS22525 (A7P61_22525) 3878589..3879830 + 1242 WP_010672044.1 peptide antibiotic transporter SbmA -
A7P61_RS22530 (A7P61_22530) 3880065..3880418 + 354 WP_064704967.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7P61_RS22535 (A7P61_22535) 3880418..3880717 + 300 WP_010252120.1 XRE family transcriptional regulator Antitoxin
A7P61_RS22540 (A7P61_22540) 3880840..3881892 - 1053 WP_064704968.1 YncE family protein -
A7P61_RS22545 (A7P61_22545) 3882090..3882305 - 216 WP_064704969.1 DUF1471 domain-containing protein -
A7P61_RS22550 (A7P61_22550) 3882518..3883705 - 1188 WP_064704970.1 MFS transporter -
A7P61_RS22555 (A7P61_22555) 3883810..3884775 + 966 WP_064704971.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13625.60 Da        Isoelectric Point: 6.9525

>T276809 WP_064704967.1 NZ_CP122328:3880065-3880418 [Pantoea agglomerans pv. betae]
MWTVLLSPRFESWLSEQEEALQEKMLADPGKLKVYGPDLPRPYADTLKGSQYRNMKELCVQFSGKPFRAFYAFDPVRQAI
VLCAGDKSHDKRFYIRMIRIADDEFSAWLAEQEKGNN

Download         Length: 354 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11116.99 Da        Isoelectric Point: 6.3781

>AT276809 WP_010252120.1 NZ_CP122328:3880418-3880717 [Pantoea agglomerans pv. betae]
MRTLDDVIADFSPESQARIKKMSDEMILEVGLQMIREELQLSQKTLAEAMGVRQPAVAQIEQRGNEIKVATLKRYVEAMG
GKLSLDVELPTGKRVAFRI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References