Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1580005..1580665 Replicon chromosome
Accession NZ_CP122328
Organism Pantoea agglomerans pv. betae strain 4188

Toxin (Protein)


Gene name higB Uniprot ID A0A349IFT5
Locus tag A7P61_RS11540 Protein ID WP_010670918.1
Coordinates 1580005..1580358 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7P61_RS11545 Protein ID WP_064703672.1
Coordinates 1580363..1580665 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P61_RS11525 (A7P61_11525) 1575585..1575984 + 400 Protein_1421 cell envelope integrity TolA C-terminal domain-containing protein -
A7P61_RS11530 (A7P61_11530) 1576061..1578223 - 2163 WP_074399975.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
A7P61_RS11535 (A7P61_11535) 1578618..1579706 + 1089 WP_064703788.1 YncE family protein -
A7P61_RS11540 (A7P61_11540) 1580005..1580358 + 354 WP_010670918.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7P61_RS11545 (A7P61_11545) 1580363..1580665 + 303 WP_064703672.1 XRE family transcriptional regulator Antitoxin
A7P61_RS11550 (A7P61_11550) 1580873..1581769 - 897 WP_064703671.1 LysR family transcriptional regulator -
A7P61_RS11555 (A7P61_11555) 1581912..1582778 + 867 WP_064703670.1 SDR family NAD(P)-dependent oxidoreductase -
A7P61_RS11560 (A7P61_11560) 1582742..1583623 + 882 WP_231115744.1 SMP-30/gluconolactonase/LRE family protein -
A7P61_RS11570 (A7P61_11570) 1584331..1585254 + 924 WP_031591254.1 sugar ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13649.71 Da        Isoelectric Point: 8.4949

>T276805 WP_010670918.1 NZ_CP122328:1580005-1580358 [Pantoea agglomerans pv. betae]
VWMIKTTERFDRWFTLLNESDRACVLAALMVLREKGPGLSRPYADTLKGSVYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYQEMLPVADREFTHWLNSFKDEE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10913.71 Da        Isoelectric Point: 5.7251

>AT276805 WP_064703672.1 NZ_CP122328:1580363-1580665 [Pantoea agglomerans pv. betae]
MGKTLEQLIADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHYGFEV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A349IFT5

Antitoxin

Source ID Structure

References