Detailed information of TA system TA276791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 3582814..3584144
• Replicon: chromosome
• Accession: NZ_CP122320
• Organism: Pantoea agglomerans pv. gypsophilae strain 824-1

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: A7P62_RS17075
• Protein ID: WP_064690197.1
• Coordinates: 3583122..3584144 (+)
• Length: 341 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A8X8DQB2
• Locus tag: A7P62_RS17070
• Protein ID: WP_033758331.1
• Coordinates: 3582814..3583125 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7P62_RS17045 (3578270)	3578270..3579652	+	1383	WP_061901305.1	D-arabinono-1,4-lactone oxidase	-
A7P62_RS17050 (3579665)	3579665..3580495	+	831	WP_045140262.1	glycosyltransferase family 8 protein	-
A7P62_RS17055 (3580586)	3580586..3581707	-	1122	WP_064690196.1	Gfo/Idh/MocA family oxidoreductase	-
A7P62_RS17065 (3582485)	3582485..3582829	+	345	WP_010247978.1	helix-turn-helix transcriptional regulator	-
A7P62_RS17070 (3582814)	3582814..3583125	+	312	WP_033758331.1	HipA N-terminal domain-containing protein	Antitoxin
A7P62_RS17075 (3583122)	3583122..3584144	+	1023	WP_064690197.1	HipA domain-containing protein	Toxin
A7P62_RS17080 (3584270)	3584270..3586489	-	2220	WP_064690198.1	catalase/peroxidase HPI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (58-302)

Antitoxin

• HipA, N-terminal subdomain 1 (6-98)

Sequences

Toxin

Protein

• Length: 341 a.a.
• Molecular weight: 38568.16 Da
• Isoelectric Point: 6.8344

>T276791 WP_064690197.1 NZ_CP122320:3583122-3584144 [Pantoea agglomerans pv. gypsophilae]
MNSERCLITLKRLKESELKTGYSTKGIRHLLGSLNVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLAKGELVVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFDVPPFGLMPFRHDENRPDELAFVIKRYDRTASDYARLHQEQLDGAMG
LGDKYGRIDNHKAISYEKAAKFLNTRVNSSLKSKRDLFLRIVYAYVLGNNDFHLRNIGIILPPQGSPWLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAGNAPGMNSEYGEYLGADFILLAQGIDINPTLARKWLSEVVSHHQLIIDTYNESHMPESQ
REAVLDYVARRITLLAVTEI

Nucleotide

• Length: 1023 bp

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11669.46 Da
• Isoelectric Point: 4.7953

>AT276791 WP_033758331.1 NZ_CP122320:3582814-3583125 [Pantoea agglomerans pv. gypsophilae]
MARKIEVWLYNTLAGTLSEGQSGYTFCYLPTYVGCAISLSMPVRPEPYLSEELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMENGNDLLGAVVFKEITS

Nucleotide

• Length: 312 bp